HLA-B locus products resist degradation by the human cytomegalovirus immunoevasin US11.

HLA-B locus products resist degradation by the human cytomegalovirus immunoevasin US11.

To escape CD8+ T-cell immunity, human cytomegalovirus (HCMV) US11 redirects MHC-I for rapid ER-associated proteolytic degradation (ERAD). In humans, classical MHC-I molecules are encoded by the highly polymorphic HLA-A, -B and -C gene loci. While HLA-C resists US11 degradation, the specificity for H...

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Bibliographic Details
Main Authors: Cosima Zimmermann, Daniel Kowalewski, Liane Bauersfeld, Andreas Hildenbrand, Carolin Gerke, Magdalena Schwarzmüller, Vu Thuy Khanh Le-Trilling, Stefan Stevanovic, Hartmut Hengel, Frank Momburg, Anne Halenius
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008040

Internet

https://doi.org/10.1371/journal.ppat.1008040

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