Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions

Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions

Satb1 is a master regulator of multiple cellular processes. Here the authors find that Satb1 preferentially targets nucleosome dense regions and combinatorially uses multiple selection criteria including DNA torsion, flanking DNA shape, motif density and periodicity to streamline binding choices.

Bibliographic Details
Main Authors: Rajarshi P. Ghosh, Quanming Shi, Linfeng Yang, Michael P. Reddick, Tatiana Nikitina, Victor B. Zhurkin, Polly Fordyce, Timothy J. Stasevich, Howard Y. Chang, William J. Greenleaf, Jan T. Liphardt
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11118-8

Internet

https://doi.org/10.1038/s41467-019-11118-8

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