High-throughput single-cell chromatin accessibility CRISPR screens enable unbiased identification of regulatory networks in cancer

by Sarah E. Pierce, Jeffrey M. Granja, William J. Greenleaf
Published 2021-05-01

Comprehensive sequence-to-function mapping of cofactor-dependent RNA catalysis in the glmS ribozyme

by Johan O. L. Andreasson, Andrew Savinov, Steven M. Block, William J. Greenleaf
Published 2020-04-01

An optimized ATAC-seq protocol for genome-wide mapping of active regulatory elements in primary mouse cortical neurons

by Maya Maor-Nof, Zohar Shipony, Georgi K. Marinov, William J. Greenleaf, Aaron D. Gitler
Published 2021-12-01

Unsupervised clustering and epigenetic classification of single cells

by Mahdi Zamanighomi, Zhixiang Lin, Timothy Daley, Xi Chen, Zhana Duren, Alicia Schep, William J. Greenleaf, Wing Hung Wong
Published 2018-06-01

INO80 Chromatin Remodeling Coordinates Metabolic Homeostasis with Cell Division

by Graeme J. Gowans, Alicia N. Schep, Ka Man Wong, Devin A. King, William J. Greenleaf, Ashby J. Morrison
Published 2018-01-01

Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity

by Xingqi Chen, Ulrike M. Litzenburger, Yuning Wei, Alicia N. Schep, Edward L. LaGory, Hani Choudhry, Amato J. Giaccia, William J. Greenleaf, Howard Y. Chang
Published 2018-11-01

Satb1 integrates DNA binding site geometry and torsional stress to differentially target nucleosome-dense regions

by Rajarshi P. Ghosh, Quanming Shi, Linfeng Yang, Michael P. Reddick, Tatiana Nikitina, Victor B. Zhurkin, Polly Fordyce, Timothy J. Stasevich, Howard Y. Chang, William J. Greenleaf, Jan T. Liphardt
Published 2019-07-01

A Conditional System to Specifically Link Disruption of Protein-Coding Function with Reporter Expression in Mice

by Shin-Heng Chiou, Caroline Kim-Kiselak, Viviana I. Risca, Megan K. Heimann, Chen-Hua Chuang, Aurora A. Burds, William J. Greenleaf, Tyler E. Jacks, David M. Feldser, Monte M. Winslow
Published 2014-06-01

Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

by David W. Morgens, Michael Wainberg, Evan A. Boyle, Oana Ursu, Carlos L. Araya, C. Kimberly Tsui, Michael S. Haney, Gaelen T. Hess, Kyuho Han, Edwin E. Jeng, Amy Li, Michael P. Snyder, William J. Greenleaf, Anshul Kundaje, Michael C. Bassik
Published 2017-05-01

Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements

by Josh Tycko, Michael Wainberg, Georgi K. Marinov, Oana Ursu, Gaelen T. Hess, Braeden K. Ego, Aradhana, Amy Li, Alisa Truong, Alexandro E. Trevino, Kaitlyn Spees, David Yao, Irene M. Kaplow, Peyton G. Greenside, David W. Morgens, Douglas H. Phanstiel, Michael P. Snyder, Lacramioara Bintu, William J. Greenleaf, Anshul Kundaje, Michael C. Bassik
Published 2019-09-01