Synthesis and Biological Evaluation of 1‑(Diarylmethyl)‑1<i>H</i>‑1,2,4‑Triazoles and 1‑(Diarylmethyl)‑1<i>H</i>‑Imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer

Synthesis and Biological Evaluation of 1‑(Diarylmethyl)‑1<i>H</i>‑1,2,4‑Triazoles and 1‑(Diarylmethyl)‑1<i>H</i>‑Imidazoles as a Novel Class of Anti-Mitotic Agent for Activity in Breast Cancer

We report the synthesis and biochemical evaluation of compounds that are designed as hybrids of the microtubule targeting benzophenone phenstatin and the aromatase inhibitor letrozole. A preliminary screening in estrogen receptor (ER)-positive MCF-7 breast cancer cells identified 5-((2<i>H<...

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Bibliographic Details
Main Authors: Gloria Ana, Patrick M. Kelly, Azizah M. Malebari, Sara Noorani, Seema M. Nathwani, Brendan Twamley, Darren Fayne, Niamh M. O’Boyle, Daniela M. Zisterer, Elisangela Flavia Pimentel, Denise Coutinho Endringer, Mary J. Meegan
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceuticals
Subjects:
phenstatin
letrozole
tubulin polymerisation inhibitor
aromatase inhibitor
breast cancer
hybrid molecule
Online Access:https://www.mdpi.com/1424-8247/14/2/169

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https://www.mdpi.com/1424-8247/14/2/169

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