GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's disease model.

GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's disease model.

OBJECTIVES: Glucagon-like peptide 2 (GLP2) is an intestinal growth factor that has been shown to stimulate intestinal growth and reduce disease severity in preclinical models of short bowel syndrome and inflammatory bowel disease. Teduglutide, a recombinant human GLP2 variant (GLP2-2G), has increase...

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Bibliographic Details
Main Authors: Susan E Alters, Bryant McLaughlin, Benjamin Spink, Tigran Lachinyan, Chia-wei Wang, Vladimir Podust, Volker Schellenberger, Willem P C Stemmer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3506575?pdf=render

Internet

http://europepmc.org/articles/PMC3506575?pdf=render

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