A ligation-based single-stranded library preparation method to analyze cell-free DNA and synthetic oligos

A ligation-based single-stranded library preparation method to analyze cell-free DNA and synthetic oligos

Abstract Background Cell-free DNA (cfDNA), present in circulating blood plasma, contains information about prenatal health, organ transplant reception, and cancer presence and progression. Originally developed for the genomic analysis of highly degraded ancient DNA, single-stranded DNA (ssDNA) libra...

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Bibliographic Details
Main Authors: Christopher J. Troll, Joshua Kapp, Varsha Rao, Kelly M. Harkins, Charles Cole, Colin Naughton, Jessica M. Morgan, Beth Shapiro, Richard E. Green
Format: Article
Language:English
Published: BMC 2019-12-01
Series:BMC Genomics
Subjects:
SRSLY
Single-stranded library
Next-generation sequencing
Cell-free DNA
Oligos
Nucleosome positioning
Online Access:https://doi.org/10.1186/s12864-019-6355-0

Internet

https://doi.org/10.1186/s12864-019-6355-0

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