Restoration of fitness lost due to dysregulation of the pyruvate dehydrogenase complex is triggered by ribosomal binding site modifications

Restoration of fitness lost due to dysregulation of the pyruvate dehydrogenase complex is triggered by ribosomal binding site modifications

Summary: Pyruvate dehydrogenase complex (PDC) functions as the main determinant of the respiro-fermentative balance because it converts pyruvate to acetyl-coenzyme A (CoA), which then enters the TCA (tricarboxylic acid cycle). PDC is repressed by the pyruvate dehydrogenase complex regulator (PdhR) i...

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Bibliographic Details
Main Authors: Amitesh Anand, Connor A. Olson, Anand V. Sastry, Arjun Patel, Richard Szubin, Laurence Yang, Adam M. Feist, Bernhard O. Palsson
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
adaptive laboratory evolution
system biology
proteome allocation
transcriptional regulatory network
bioenergetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002758

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http://www.sciencedirect.com/science/article/pii/S2211124721002758

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