Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Indispensable epigenetic control of thymic epithelial cell development and function by polycomb repressive complex 2

Development of the T cells requires functions from thymic epithelial cells, whose development and function are epigenetically regulated. Here the authors show that inactivation of the polycomb repressive complex 2 (PRC2) alters the H3K27me3 configuration, reduces TEC functions, reveals a specific TE...

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Bibliographic Details
Main Authors: Thomas Barthlott, Adam E. Handel, Hong Ying Teh, Rushika C. Wirasinha, Katrin Hafen, Saulius Žuklys, Benoit Roch, Stuart H. Orkin, Jean-Pierre de Villartay, Stephen R. Daley, Georg A. Holländer
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24158-w

Internet

https://doi.org/10.1038/s41467-021-24158-w

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