Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury.

Pre-treatment with allopurinol or uricase attenuates barrier dysfunction but not inflammation during murine ventilator-induced lung injury.

Uric acid released from injured tissue is considered a major endogenous danger signal and local instillation of uric acid crystals induces acute lung inflammation via activation of the NLRP3 inflammasome. Ventilator-induced lung injury (VILI) is mediated by the NLRP3 inflammasome and increased uric...

Full description

Bibliographic Details
Main Authors: Maria T Kuipers, Hamid Aslami, Alexander P J Vlaar, Nicole P Juffermans, Anita M Tuip-de Boer, Maria A Hegeman, Geartsje Jongsma, Joris J T H Roelofs, Tom van der Poll, Marcus J Schultz, Catharina W Wieland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3511544?pdf=render

Internet

http://europepmc.org/articles/PMC3511544?pdf=render

Similar Items