Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice

Adenosine A2A receptor inhibition reduces synaptic and cognitive hippocampal alterations in Fmr1 KO mice

Abstract In fragile X syndrome (FXS) the lack of the fragile X mental retardation protein (FMRP) leads to exacerbated signaling through the metabotropic glutamate receptors 5 (mGlu5Rs). The adenosine A2A receptors (A2ARs), modulators of neuronal damage, could play a role in FXS. A synaptic colocaliz...

Full description

Bibliographic Details
Main Authors: Antonella Ferrante, Zaira Boussadia, Antonella Borreca, Cinzia Mallozzi, Giorgia Pedini, Laura Pacini, Antonella Pezzola, Monica Armida, Fabrizio Vincenzi, Katia Varani, Claudia Bagni, Patrizia Popoli, Alberto Martire
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-021-01238-5

Internet

https://doi.org/10.1038/s41398-021-01238-5

Similar Items