Genotype–phenotype associations of polymorphisms within the gene locus of NOD-like receptor pyrin domain containing 3 in Swiss inflammatory bowel disease patients

Genotype–phenotype associations of polymorphisms within the gene locus of NOD-like receptor pyrin domain containing 3 in Swiss inflammatory bowel disease patients

Abstract Background Genetic variations within the regulatory region of the gene encoding NOD-like receptor pyrin domain containing 3 (NLRP3) have been associated with Crohn’s Disease (CD). NLRP3 is part of the NLRP3-inflammasome that mediates the maturation of IL-1β and IL-18. Carrying the major all...

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Main Authors: Priyatharsan Yoganathan, Jean-Benoit Rossel, Sebastian Bruno Ulrich Jordi, Yannick Franc, Luc Biedermann, Benjamin Misselwitz, Martin Hausmann, Gerhard Rogler, Michael Scharl, Isabelle Frey-Wagner, Swiss IBD cohort study group
Format: Article
Language:English
Published: BMC 2021-08-01
Series:BMC Gastroenterology
Subjects:
NLRP3 inflammasome
Inflammatory bowel disease
Single nucleotide polymorphisms
Clinical characteristics
Online Access:https://doi.org/10.1186/s12876-021-01880-9

Internet

https://doi.org/10.1186/s12876-021-01880-9

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