Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis

Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis

Summary: Pneumonias caused by influenza A virus (IAV) co- and secondary bacterial infections are characterized by their severity and high mortality rate. Previously, we have shown that bacterial pore-forming toxin (PFT)-mediated necroptosis is a key driver of acute lung injury during bacterial pneum...

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Bibliographic Details
Main Authors: Norberto Gonzalez-Juarbe, Ashleigh N. Riegler, Alexander S. Jureka, Ryan P. Gilley, Jeffrey D. Brand, John E. Trombley, Ninecia R. Scott, Maryann P. Platt, Peter H. Dube, Chad M. Petit, Kevin S. Harrod, Carlos J. Orihuela
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports
Subjects:
pneumonia
influenza A virus
Streptococcus pneumoniae
epithelial cells
necroptosis
cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720310470

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http://www.sciencedirect.com/science/article/pii/S2211124720310470

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