Sugar-Coated Killer: Serotype 3 Pneumococcal Disease

by Jennifer N. Luck, Hervé Tettelin, Carlos J. Orihuela
Published 2020-12-01

Opening the OPK Assay Gatekeeper: Harnessing Multi-Modal Protection by Pneumococcal Vaccines

by Ashleigh N. Riegler, Beth Mann, Carlos J. Orihuela, Elaine Tuomanen
Published 2019-10-01

Killing of Serratia marcescens biofilms with chloramphenicol

by Christopher Ray, Anukul T. Shenoy, Carlos J. Orihuela, Norberto González-Juarbe
Published 2017-03-01

Multi-Valent Protein Hybrid Pneumococcal Vaccines: A Strategy for the Next Generation of Vaccines

by Ninecia R. Scott, Beth Mann, Elaine I. Tuomanen, Carlos J. Orihuela
Published 2021-03-01

Necroptotic Cell Death Promotes Adaptive Immunity Against Colonizing Pneumococci

by Ashleigh Nichole Riegler, Terry Brissac, Norberto Gonzalez-Juarbe, Carlos J. Orihuela
Published 2019-04-01

Interactions between blood-borne Streptococcus pneumoniae and the blood-brain barrier preceding meningitis.

by Federico Iovino, Carlos J Orihuela, Henk E Moorlag, Grietje Molema, Jetta J E Bijlsma
Published 2013-01-01

YopE specific CD8+ T cells provide protection against systemic and mucosal Yersinia pseudotuberculosis infection.

by Norberto González-Juarbe, Haiqian Shen, Molly A Bergman, Carlos J Orihuela, Peter H Dube
Published 2017-01-01

NAD+ Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis

by David Pajuelo, Norberto Gonzalez-Juarbe, Uday Tak, Jim Sun, Carlos J. Orihuela, Michael Niederweis
Published 2018-07-01

Severity and properties of cardiac damage caused by Streptococcus pneumoniae are strain dependent.

by Anukul T Shenoy, Sarah M Beno, Terry Brissac, Jeremiah W Bell, Lea Novak, Carlos J Orihuela
Published 2018-01-01

Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniae.

by Laura Selva, Pilar Ciruela, Krystle Blanchette, Eva del Amo, Roman Pallares, Carlos J Orihuela, Carmen Muñoz-Almagro
Published 2012-01-01

Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and impact virulence.

by Carlos J Sanchez, Cecilia A Hinojosa, Pooja Shivshankar, Catherine Hyams, Emilie Camberlein, Jeremy S Brown, Carlos J Orihuela
Published 2011-01-01

Streptococcus pneumoniae in biofilms are unable to cause invasive disease due to altered virulence determinant production.

by Carlos J Sanchez, Nikhil Kumar, Anel Lizcano, Pooja Shivshankar, Julie C Dunning Hotopp, James H Jorgensen, Hervé Tettelin, Carlos J Orihuela
Published 2011-01-01

The pneumococcal serine-rich repeat protein is an intra-species bacterial adhesin that promotes bacterial aggregation in vivo and in biofilms.

by Carlos J Sanchez, Pooja Shivshankar, Kim Stol, Samuel Trakhtenbroit, Paul M Sullam, Karin Sauer, Peter W M Hermans, Carlos J Orihuela
Published 2010-08-01

Streptococcus pneumoniae binds to host GAPDH on dying lung epithelial cells worsening secondary infection following influenza

by Sang-Sang Park, Norberto Gonzalez-Juarbe, Ashleigh N. Riegler, Hansol Im, Yvette Hale, Maryann P. Platt, Christina Croney, David E. Briles, Carlos J. Orihuela
Published 2021-06-01

Streptococcus pneumoniae in the heart subvert the host response through biofilm-mediated resident macrophage killing.

by Anukul T Shenoy, Terry Brissac, Ryan P Gilley, Nikhil Kumar, Yong Wang, Norberto Gonzalez-Juarbe, Whitney S Hinkle, Sean C Daugherty, Amol C Shetty, Sandra Ott, Luke J Tallon, Jessy Deshane, Hervé Tettelin, Carlos J Orihuela
Published 2017-08-01

Influenza-Induced Oxidative Stress Sensitizes Lung Cells to Bacterial-Toxin-Mediated Necroptosis

by Norberto Gonzalez-Juarbe, Ashleigh N. Riegler, Alexander S. Jureka, Ryan P. Gilley, Jeffrey D. Brand, John E. Trombley, Ninecia R. Scott, Maryann P. Platt, Peter H. Dube, Chad M. Petit, Kevin S. Harrod, Carlos J. Orihuela
Published 2020-08-01

Splenic macrophages as the source of bacteraemia during pneumococcal pneumonia

by David Carreno, Joseph J Wanford, Zydrune Jasiunaite, Ryan G. Hames, Wen Y Chung, Ashley R. Dennison, Kornelis Straatman, Luisa Martinez-Pomares, Manish Pareek, Carlos J. Orihuela, Marcos I. Restrepo, Wei Shen Lim, Peter W. Andrew, E. Richard Moxon, Marco R Oggioni
Published 2021-10-01

A Non-Human Primate Model of Severe Pneumococcal Pneumonia.

by Luis F Reyes, Marcos I Restrepo, Cecilia A Hinojosa, Nilam J Soni, Anukul T Shenoy, Ryan P Gilley, Norberto Gonzalez-Juarbe, Julio R Noda, Vicki T Winter, Melissa A de la Garza, Robert E Shade, Jacqueline J Coalson, Luis D Giavedoni, Antonio Anzueto, Carlos J Orihuela
Published 2016-01-01

Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function.

by Armand O Brown, Beth Mann, Geli Gao, Jane S Hankins, Jessica Humann, Jonathan Giardina, Paola Faverio, Marcos I Restrepo, Ganesh V Halade, Eric M Mortensen, Merry L Lindsey, Martha Hanes, Kyle I Happel, Steve Nelson, Gregory J Bagby, Jose A Lorent, Pablo Cardinal, Rosario Granados, Andres Esteban, Claude J LeSaux, Elaine I Tuomanen, Carlos J Orihuela
Published 2014-09-01