Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2

Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2

Due to their system of annulated 6-5-5-6-membered rings, indenoindoles have sparked great interest for the design of ATP-competitive inhibitors of human CK2. In the present study, we prepared twenty-one indeno[1,2-b]indole derivatives, all of which were tested in vitro on human CK2. The indenoindolo...

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Bibliographic Details
Main Authors: Faten Alchab, Laurent Ettouati, Zouhair Bouaziz, Andre Bollacke, Jean-Guy Delcros, Christoph G.W. Gertzen, Holger Gohlke, Noël Pinaud, Mathieu Marchivie, Jean Guillon, Bernard Fenet, Joachim Jose, Marc Le Borgne
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Pharmaceuticals
Subjects:
indeno[1,2-b]indoles
synthesis
protein kinase CK2
inhibitory activity
molecular modeling
cytotoxicity
Online Access:http://www.mdpi.com/1424-8247/8/2/279

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http://www.mdpi.com/1424-8247/8/2/279

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