Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways

Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways

Abstract Background Leptin plays a critical role in the regulation of metabolic homeostasis. However, the molecular mechanism and cross talks between leptin and metabolic pathways leading to metabolic homeostasis across different species are not clear. This study aims to explore the effects of lepti...

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Bibliographic Details
Main Authors: Yi Ding, Mariëlle C. Haks, Gabriel Forn-Cuní, Junling He, Natalia Nowik, Amy C. Harms, Thomas Hankemeier, Muhamed N. H. Eeza, Jörg Matysik, A. Alia, Herman P. Spaink
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Cell & Bioscience
Subjects:
Ob/ob mice
Leptin mutant zebrafish
Diabetes
Metabolomics
Transcriptomics
Wasting syndrome
Online Access:https://doi.org/10.1186/s13578-021-00642-0

Internet

https://doi.org/10.1186/s13578-021-00642-0

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