Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represen...

by Krista E van Meijgaarden, Mariëlle C Haks, Nadia Caccamo, Francesco Dieli, Tom H M Ottenhoff, Simone A Joosten
Published 2015-03-01

Impaired Immune Response to Primary but Not to Booster Vaccination Against Hepatitis B in Older Adults

by Birgit Weinberger, Mariëlle C. Haks, Roelof A. de Paus, Tom H. M. Ottenhoff, Tanja Bauer, Beatrix Grubeck-Loebenstein
Published 2018-05-01

Gene expression profiles classifying clinical stages of tuberculosis and monitoring treatment responses in Ethiopian HIV-negative and HIV-positive cohorts.

by Gebremedhin Gebremicael, Desta Kassa, Yodit Alemayehu, Atsbeha Gebreegziaxier, Yonas Kassahun, Debbie van Baarle, Tom H M Ottenhoff, Jacqueline M Cliff, Mariëlle C Haks
Published 2019-01-01

Metabolomic and transcriptomic profiling of adult mice and larval zebrafish leptin mutants reveal a common pattern of changes in metabolites and signaling pathways

by Yi Ding, Mariëlle C. Haks, Gabriel Forn-Cuní, Junling He, Natalia Nowik, Amy C. Harms, Thomas Hankemeier, Muhamed N. H. Eeza, Jörg Matysik, A. Alia, Herman P. Spaink
Published 2021-07-01

Biomarkers Can Identify Pulmonary Tuberculosis in HIV-infected Drug Users Months Prior to Clinical Diagnosis

by Rosa Sloot, Maarten F. Schim van der Loeff, Erik W. van Zwet, Mariëlle C. Haks, Sytze T. Keizer, Maarten Scholing, Tom H.M. Ottenhoff, Martien W. Borgdorff, Simone A. Joosten
Published 2015-02-01

Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children

by John Espen Gjøen, Synne Jenum, Dhanasekaran Sivakumaran, Aparna Mukherjee, Ragini Macaden, Sushil K. Kabra, Rakesh Lodha, Tom H. M. Ottenhoff, Marielle C. Haks, Timothy Mark Doherty, Christian Ritz, Harleen M. S. Grewal
Published 2017-07-01

Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials

by Cornelis J. Korbee, Matthias T. Heemskerk, Dragi Kocev, Elisabeth van Strijen, Omid Rabiee, Kees L. M. C. Franken, Louis Wilson, Nigel D. L. Savage, Sašo Džeroski, Mariëlle C. Haks, Tom H. M. Ottenhoff
Published 2018-01-01

Identification of probable early-onset biomarkers for tuberculosis disease progression.

by Jayne S Sutherland, Philip C Hill, Ifedayo M Adetifa, Bouke C de Jong, Simon Donkor, Simone A Joosten, Lizet Opmeer, Marielle C Haks, Tom H M Ottenhoff, Richard A Adegbola, Martin O C Ota
Published 2011-01-01

Heterologous Protection against Malaria after Immunization with Plasmodium falciparum Sporozoites.

by Remko Schats, Else M Bijker, Geert-Jan van Gemert, Wouter Graumans, Marga van de Vegte-Bolmer, Lisette van Lieshout, Mariëlle C Haks, Cornelus C Hermsen, Anja Scholzen, Leo G Visser, Robert W Sauerwein
Published 2015-01-01

Host Immune Responses Differ between M. africanum- and M. tuberculosis-Infected Patients following Standard Anti-tuberculosis Treatment.

by Leopold D Tientcheu, Mariëlle C Haks, Schadrac C Agbla, Jayne S Sutherland, Ifedayo M Adetifa, Simon Donkor, Edwin Quinten, Mohammed Daramy, Martin Antonio, Beate Kampmann, Tom H M Ottenhoff, Hazel M Dockrell, Martin O Ota
Published 2016-05-01

Human Transcriptomic Response to the VSV-Vectored Ebola Vaccine

by Francesco Santoro, Alessia Donato, Simone Lucchesi, Sara Sorgi, Alice Gerlini, Marielle C. Haks, Tom H. M. Ottenhoff, Patricia Gonzalez-Dias, VSV-EBOVAC Consortium, VSV-EBOPLUS Consortium, Helder I. Nakaya, Angela Huttner, Claire-Anne Siegrist, Donata Medaglini, Gianni Pozzi
Published 2021-01-01

Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish

by Jôsimar D. Moreira, Jôsimar D. Moreira, Bjørn E. V. Koch, Suzanne van Veen, Kimberley V. Walburg, Frank Vrieling, Tânia Mara Pinto Dabés Guimarães, Annemarie H. Meijer, Herman P. Spaink, Tom H. M. Ottenhoff, Mariëlle C. Haks, Matthias T. Heemskerk
Published 2020-02-01

Molecular Signatures of Immunity and Immunogenicity in Infection and Vaccination

by Mariëlle C. Haks, Barbara Bottazzi, Valentina Cecchinato, Corinne De Gregorio, Giuseppe Del Giudice, Stefan H. E. Kaufmann, Antonio Lanzavecchia, David J. M. Lewis, Jeroen Maertzdorf, Alberto Mantovani, Alberto Mantovani, Federica Sallusto, Federica Sallusto, Marina Sironi, Mariagrazia Uguccioni, Mariagrazia Uguccioni, Tom H. M. Ottenhoff
Published 2017-11-01