CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance.
Current thinking emphasizes the primacy of CD14 in facilitating recognition of microbes by certain TLRs to initiate pro-inflammatory signaling events and the importance of p38-MAPK in augmenting such responses. Herein, this paradigm is challenged by demonstrating that recognition of live Borrelia bu...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2009-12-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC2781632?pdf=render |