Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity.

Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity.

The transcription factor sterol regulatory element binding protein (SREBP)-1a plays a pivotal role in lipid metabolism. Using the SREBP-1a expressing human hepatoma cell line HepG2 we have shown previously that human SREBP-1a is phosphorylated at serine 117 by ERK-mitogen-activated protein kinases (...

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Bibliographic Details
Main Authors: Jorg Kotzka, Birgit Knebel, Jutta Haas, Lorena Kremer, Sylvia Jacob, Sonja Hartwig, Ulrike Nitzgen, Dirk Muller-Wieland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22384276/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22384276/?tool=EBI

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