Lipodystrophies—Disorders of the Fatty Tissue

by Birgit Knebel, Dirk Müller-Wieland, Jorg Kotzka
Published 2020-11-01

Preventing phosphorylation of sterol regulatory element-binding protein 1a by MAP-kinases protects mice from fatty liver and visceral obesity.

by Jorg Kotzka, Birgit Knebel, Jutta Haas, Lorena Kremer, Sylvia Jacob, Sonja Hartwig, Ulrike Nitzgen, Dirk Muller-Wieland
Published 2012-01-01

Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass.

by Birgit Knebel, Jutta Haas, Sonja Hartwig, Sylvia Jacob, Cornelia Köllmer, Ulrike Nitzgen, Dirk Muller-Wieland, Jorg Kotzka
Published 2012-01-01

Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade

by Jörg Kotzka, Dirk Müller-Wieland, Gunther Roth, Lorena Kremer, Martina Munck, Sandra Schürmann, Birgit Knebel, Wilhelm Krone
Published 2000-01-01

Clinical course of COVID-19 patients needing supplemental oxygen outside the intensive care unit

by Ayham Daher, Paul Balfanz, Maria Aetou, Bojan Hartmann, Dirk Müller-Wieland, Tobias Müller, Nikolaus Marx, Michael Dreher, Christian G. Cornelissen
Published 2021-01-01

Elevated serum SDMA and ADMA at hospital admission predict in-hospital mortality of COVID-19 patients

by Juliane Hannemann, Paul Balfanz, Edzard Schwedhelm, Bojan Hartmann, Johanna Ule, Dirk Müller-Wieland, Edgar Dahl, Michael Dreher, Nikolaus Marx, Rainer Böger
Published 2021-05-01

Inactivation of SREBP-1a Phosphorylation Prevents Fatty Liver Disease in Mice: Identification of Related Signaling Pathways by Gene Expression Profiles in Liver and Proteomes of Pe...

by Birgit Knebel, Sonja Hartwig, Sylvia Jacob, Ulrike Kettel, Martina Schiller, Waltraud Passlack, Cornelia Koellmer, Stefan Lehr, Dirk Müller-Wieland, Jorg Kotzka
Published 2018-03-01

Adipokinome Signatures in Obese Mouse Models Reflect Adipose Tissue Health and Are Associated with Serum Lipid Composition

by Birgit Knebel, Pia Fahlbusch, Gereon Poschmann, Matthias Dille, Natalie Wahlers, Kai Stühler, Sonja Hartwig, Stefan Lehr, Martina Schiller, Sylvia Jacob, Ulrike Kettel, Dirk Müller-Wieland, Jörg Kotzka
Published 2019-05-01

Effect of alirocumab on individuals with type 2 diabetes, high triglycerides, and low high-density lipoprotein cholesterol

by Helen M. Colhoun, Lawrence A. Leiter, Dirk Müller-Wieland, Bertrand Cariou, Kausik K. Ray, Francisco J. Tinahones, Catherine Domenger, Alexia Letierce, Marc Israel, Rita Samuel, Stefano Del Prato
Published 2020-02-01

Early risk markers for severe clinical course and fatal outcome in German patients with COVID-19.

by Paul Balfanz, Bojan Hartmann, Dirk Müller-Wieland, Michael Kleines, Dennis Häckl, Nils Kossack, Alexander Kersten, Christian Cornelissen, Tobias Müller, Ayham Daher, Robert Stöhr, Johannes Bickenbach, Gernot Marx, Nikolaus Marx, Michael Dreher
Published 2021-01-01

Alirocumab therapy in individuals with type 2 diabetes mellitus and atherosclerotic cardiovascular disease: analysis of the ODYSSEY DM-DYSLIPIDEMIA and DM-INSULIN studies

by Kausik K. Ray, Stefano Del Prato, Dirk Müller-Wieland, Bertrand Cariou, Helen M. Colhoun, Francisco J. Tinahones, Catherine Domenger, Alexia Letierce, Jonas Mandel, Rita Samuel, Maja Bujas-Bobanovic, Lawrence A. Leiter
Published 2019-11-01

Reliable Detection of Atrial Fibrillation with a Medical Wearable during Inpatient Conditions

by Malte Jacobsen, Till A. Dembek, Athanasios-Panagiotis Ziakos, Rahil Gholamipoor, Guido Kobbe, Markus Kollmann, Christoph Blum, Dirk Müller-Wieland, Andreas Napp, Lutz Heinemann, Nikolas Deubner, Nikolaus Marx, Stefan Isenmann, Melchior Seyfarth
Published 2020-09-01

Design and rationale of the ODYSSEY DM-DYSLIPIDEMIA trial: lipid-lowering efficacy and safety of alirocumab in individuals with type 2 diabetes and mixed dyslipidaemia at high card...

by Dirk Müller-Wieland, Lawrence A. Leiter, Bertrand Cariou, Alexia Letierce, Helen M. Colhoun, Stefano Del Prato, Robert R. Henry, Francisco J. Tinahones, Lisa Aurand, Jaman Maroni, Kausik K. Ray, Maja Bujas-Bobanovic
Published 2017-05-01

Physiological Disturbance in Fatty Liver Energy Metabolism Converges on IGFBP2 Abundance and Regulation in Mice and Men

by Pia Fahlbusch, Birgit Knebel, Tina Hörbelt, David Monteiro Barbosa, Aleksandra Nikolic, Sylvia Jacob, Hadi Al-Hasani, Frederique Van de Velde, Yves Van Nieuwenhove, Dirk Müller-Wieland, Bruno Lapauw, D. Margriet Ouwens, Jorg Kotzka
Published 2020-06-01

Six Months Follow-Up of Patients with Invasive Mechanical Ventilation due to COVID-19 Related ARDS

by Ayham Daher, Christian Cornelissen, Niels-Ulrik Hartmann, Paul Balfanz, Annegret Müller, Ingmar Bergs, Maria Aetou, Nikolaus Marx, Gernot Marx, Tim-Philipp Simon, Dirk Müller-Wieland, Bojan Hartmann, Alexander Kersten, Tobias Müller, Michael Dreher
Published 2021-05-01

Fatty Liver Due to Increased de novo Lipogenesis: Alterations in the Hepatic Peroxisomal Proteome

by Birgit Knebel, Birgit Knebel, Pia Fahlbusch, Pia Fahlbusch, Matthias Dille, Matthias Dille, Natalie Wahlers, Natalie Wahlers, Sonja Hartwig, Sonja Hartwig, Sylvia Jacob, Sylvia Jacob, Ulrike Kettel, Ulrike Kettel, Martina Schiller, Martina Schiller, Diran Herebian, Cornelia Koellmer, Cornelia Koellmer, Stefan Lehr, Stefan Lehr, Dirk Müller-Wieland, Jorg Kotzka, Jorg Kotzka
Published 2019-10-01