Functional Profiling of CFTR-Directed Therapeutics Using Pediatric Patient-Derived Nasal Epithelial Cell Models

Functional Profiling of CFTR-Directed Therapeutics Using Pediatric Patient-Derived Nasal Epithelial Cell Models

Functional profiling of CFTR-directed therapeutics offers the potential to provide significant benefits to young people with cystic fibrosis (CF). However, the development of 2D airway epithelial cell models for individual response tests in CF children remains a central task. The objective of this s...

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Bibliographic Details
Main Authors: Jeffrey KiHyun Park, Anura Shrivastava, Chengkang Zhang, Brian A. Pollok, Walter E. Finkbeiner, Elizabeth R. Gibb, Ngoc P. Ly, Beate Illek
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pediatrics
Subjects:
Cystic fibrosis
mutation-specific CFTR function analysis
CFTRdele2
3(21kb) (c.54-5940_270+10250del21 kb
p.Ser18ArgfsX16)
c.850dupA (977insA
Online Access:https://www.frontiersin.org/article/10.3389/fped.2020.00536/full

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https://www.frontiersin.org/article/10.3389/fped.2020.00536/full

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