Functional Profiling of CFTR-Directed Therapeutics Using Pediatric Patient-Derived Nasal Epithelial Cell Models

by Jeffrey KiHyun Park, Anura Shrivastava, Chengkang Zhang, Brian A. Pollok, Walter E. Finkbeiner, Elizabeth R. Gibb, Ngoc P. Ly, Beate Illek, Beate Illek
Published 2020-09-01

Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease.

by Zachary M Sellers, Beate Illek, Miriam Frankenthal Figueira, Gopika Hari, Nam Soo Joo, Eric Sibley, Jackson Souza-Menezes, Marcelo M Morales, Horst Fischer, Jeffrey J Wine
Published 2017-01-01

TALENs Facilitate Single-step Seamless SDF Correction of F508del CFTR in Airway Epithelial Submucosal Gland Cell-derived CF-iPSCs

by Shingo Suzuki, R Geoffrey Sargent, Beate Illek, Horst Fischer, Alaleh Esmaeili-Shandiz, Michael J Yezzi, Albert Lee, Yanu Yang, Soya Kim, Peter Renz, Zhongxia Qi, Jingwei Yu, Marcus O Muench, Ashley I Beyer, Alessander O Guimarães, Lin Ye, Judy Chang, Eli J Fine, Thomas J Cradick, Gang Bao, Meghdad Rahdar, Matthew H Porteus, Tsuyoshi Shuto, Hirofumi Kai, Yuet W Kan, Dieter C Gruenert
Published 2016-01-01