Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12
Wnt signalling is dependent on dishevelled proteins (DVL1-3), which assemble an intracellular Wnt signalosome at the plasma membrane. The levels of DVL1-3 are regulated by multiple Cullin-RING E3 ligases that mediate their ubiquitination and degradation. The BTB-Kelch protein KLHL12 was the first E3...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Royal Society
2020-06-01
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| Series: | Open Biology |
| Subjects: | |
| Online Access: | https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200041 |