ALK2 Receptor Kinase Association with FKBP12.6 Is Structurally Conserved with the ALK2-FKBP12 Complex

by Eleanor Williams, Elise Riesebos, Georgina Kerr, Alex N. Bullock
Published 2021-01-01

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

by Zhuoyao Chen, Gregory A. Wasney, Sarah Picaud, Panagis Filippakopoulos, Masoud Vedadi, Vincenzo D'Angiolella, Alex N. Bullock
Published 2020-06-01

Challenges and Opportunities for Drug Repositioning in Fibrodysplasia Ossificans Progressiva

by Francesc Ventura, Eleanor Williams, Makoto Ikeya, Alex N. Bullock, Peter ten Dijke, Marie-José Goumans, Gonzalo Sanchez-Duffhues
Published 2021-02-01

Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor.

by Alex N Bullock, Santina Russo, Ann Amos, Nicholas Pagano, Howard Bregman, Judit E Debreczeni, Wen Hwa Lee, Frank von Delft, Eric Meggers, Stefan Knapp
Published 2009-10-01

CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function

by Peter Canning, Kwangjin Park, João Gonçalves, Chunmei Li, Conor J. Howard, Timothy D. Sharpe, Liam J. Holt, Laurence Pelletier, Alex N. Bullock, Michel R. Leroux
Published 2018-01-01

Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients.

by Kirsten A Petrie, Wen Hwa Lee, Alex N Bullock, Jenny J Pointon, Roger Smith, R Graham G Russell, Matthew A Brown, B Paul Wordsworth, James T Triffitt
Published 2009-01-01

Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family

by Olivier E. Nonga, Darja Lavogina, Erki Enkvist, Katrin Kestav, Apirat Chaikuad, Sarah E. Dixon-Clarke, Alex N. Bullock, Sergei Kopanchuk, Taavi Ivan, Ramesh Ekambaram, Kaido Viht, Stefan Knapp, Asko Uri
Published 2021-07-01

A new class of small molecule inhibitor of BMP signaling.

by Caroline E Sanvitale, Georgina Kerr, Apirat Chaikuad, Marie-Christine Ramel, Agustin H Mohedas, Sabine Reichert, You Wang, James T Triffitt, Gregory D Cuny, Paul B Yu, Caroline S Hill, Alex N Bullock
Published 2013-01-01

Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.

by Edmond M Linossi, Indu R Chandrashekaran, Tatiana B Kolesnik, James M Murphy, Andrew I Webb, Tracy A Willson, Lukasz Kedzierski, Alex N Bullock, Jeffrey J Babon, Raymond S Norton, Nicos A Nicola, Sandra E Nicholson
Published 2013-01-01

Saracatinib is an efficacious clinical candidate for fibrodysplasia ossificans progressiva

by Eleanor Williams, Jana Bagarova, Georgina Kerr, Dong-Dong Xia, Elsie S. Place, Devaveena Dey, Yue Shen, Geoffrey A. Bocobo, Agustin H. Mohedas, Xiuli Huang, Philip E. Sanderson, Arthur Lee, Wei Zheng, Aris N. Economides, James C. Smith, Paul B. Yu, Alex N. Bullock
Published 2021-04-01

Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva‐Derived Endothelial Cells

by Gonzalo Sánchez‐Duffhues, Eleanor Williams, Pascal Benderitter, Valeria Orlova, Michiel vanWijhe, Amaya Garcia de Vinuesa, Georgina Kerr, Josselin Caradec, Kirsten Lodder, Hetty C. deBoer, Marie‐José Goumans, Elisabeth M W Eekhoff, Antonio Morales‐Piga, Javier Bachiller‐Corral, Pieter Koolwijk, Alex N. Bullock, Jan Hoflack, Peter tenDijke
Published 2019-11-01