Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3

Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3

Accumulation of mutant polyglutamine proteins in intraneuronal inclusions is a hallmark of polyglutamine diseases. Impairment of protein clearance systems and sequestration of clearance-related proteins into inclusions occur in many protein folding diseases, including polyglutamine diseases. The ubi...

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Bibliographic Details
Main Authors: Li Zeng, Bo Wang, Sean A. Merillat, Eiko N. Minakawa, Matthew D. Perkins, Biswarathan Ramani, Sara J. Tallaksen-Greene, Maria do Carmo Costa, Roger L. Albin, Henry L. Paulson
Format: Article
Language:English
Published: Elsevier 2015-10-01
Series:Neurobiology of Disease
Subjects:
UBQLN2
SCA3
Huntington's disease
Polyglutamine
UBA
UBL
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300012

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http://www.sciencedirect.com/science/article/pii/S0969996115300012

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