Mutations in APP have independent effects on Aβ and CTFγ generation
Understanding the molecular mechanism of β-amyloid (Aβ) generation is crucial for Alzheimer's disease pathogenesis as well as for normal APP function. The transmembrane domain (TM) of APP appears to undergo presenilin-dependent γ-secretase cleavage at two topologically distinct sites: a site in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2004-11-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996104001561 |