Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier.

Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier.

Changes to the structure of nodes of Ranvier in the normal-appearing white matter (NAWM) of multiple sclerosis (MS) brains are associated with chronic inflammation. We show that the paranodal domains in MS NAWM are longer on average than control, with Kv1.2 channels dislocated into the paranode. The...

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Bibliographic Details
Main Authors: Patricia Gallego-Delgado, Rachel James, Eleanor Browne, Joanna Meng, Swetha Umashankar, Li Tan, Carmen Picon, Nicholas D Mazarakis, A Aldo Faisal, Owain W Howell, Richard Reynolds
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001008

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https://doi.org/10.1371/journal.pbio.3001008

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