Structure-based discovery of potent and selective melatonin receptor agonists

Structure-based discovery of potent and selective melatonin receptor agonists

Melatonin receptors MT1 and MT2 are involved in synchronizing circadian rhythms and are important targets for treating sleep and mood disorders, type-2 diabetes and cancer. Here, we performed large scale structure-based virtual screening for new ligand chemotypes using recently solved high-resolutio...

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Bibliographic Details
Main Authors: Nilkanth Patel, Xi Ping Huang, Jessica M Grandner, Linda C Johansson, Benjamin Stauch, John D McCorvy, Yongfeng Liu, Bryan Roth, Vsevolod Katritch
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-03-01
Series:eLife
Subjects:
GPCR
virtual ligand screening
melatonin
biased signaling
Online Access:https://elifesciences.org/articles/53779

Internet

https://elifesciences.org/articles/53779

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