Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

Chemokine receptors play important roles in the immune system and are linked to several human diseases. Targeting chemokine receptors have so far shown very little success owing to, to some extent, the promiscuity of the immune system and the high degree of biased signaling within it. CCR7 and its t...

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Bibliographic Details
Main Authors: Astrid S. Jørgensen, Olav Larsen, Edith Uetz-von Allmen, Michael Lückmann, Daniel F. Legler, Thomas M. Frimurer, Christopher T. Veldkamp, Gertrud M. Hjortø, Mette M. Rosenkilde
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Immunology
Subjects:
ligand biased signaling
CCR7
CCL21
CCL19
chemokine core domain
ECL2
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02156/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02156/full

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