First‐in‐human intracochlear application of human stromal cell‐derived extracellular vesicles

First‐in‐human intracochlear application of human stromal cell‐derived extracellular vesicles

Abstract Extracellular vesicles (EVs) derived from the secretome of human mesenchymal stromal cells (MSC) contain numerous factors that are known to exert anti‐inflammatory effects. MSC‐EVs may serve as promising cell‐based therapeutics for the inner ear to attenuate inflammation‐based side effects...

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Bibliographic Details
Main Authors: Athanasia Warnecke, Nils Prenzler, Jennifer Harre, Ulrike Köhl, Lutz Gärtner, Thomas Lenarz, Sandra Laner‐Plamberger, Georg Wietzorrek, Hinrich Staecker, Teresa Lassacher, Julia Hollerweger, Mario Gimona, Eva Rohde
Format: Article
Language:English
Published: Taylor & Francis Group 2021-06-01
Series:Journal of Extracellular Vesicles
Subjects:
cochlear implantation
EVs from umbilical cord‐derived mesenchymal stromal cells (UC‐MSC‐EV)
extracellular vesicles
first‐in‐human intracochlear EV‐therapy
hearing loss
immunomodulation
Online Access:https://doi.org/10.1002/jev2.12094

Internet

https://doi.org/10.1002/jev2.12094

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