l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain

l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain

Isomerization of l-aspartyl and l-asparaginyl residues to l-isoaspartyl residues is one type of protein damage that can occur under physiological conditions and leads to conformational changes, loss of function, and enhanced protein degradation. Protein l-isoaspartyl methyltransferase (PCMT) is a re...

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Bibliographic Details
Main Authors: Remon Soliman, Maria Lorena Cordero-Maldonado, Teresa G. Martins, Mahsa Moein, Jean-François Conrotte, Rebeccah A. Warmack, Alexander Skupin, Alexander D. Crawford, Steven G. Clarke, Carole L. Linster
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Genetics
Subjects:
isoaspartyl
protein repair
zebrafish
calcium signaling
HT22 cells
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.612343/full

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https://www.frontiersin.org/articles/10.3389/fgene.2020.612343/full

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