l-Isoaspartyl Methyltransferase Deficiency in Zebrafish Leads to Impaired Calcium Signaling in the Brain

by Remon Soliman, Maria Lorena Cordero-Maldonado, Teresa G. Martins, Mahsa Moein, Jean-François Conrotte, Rebeccah A. Warmack, Alexander Skupin, Alexander Skupin, Alexander D. Crawford, Alexander D. Crawford, Steven G. Clarke, Carole L. Linster
Published 2021-01-01

Evaluation of 14 organic solvents and carriers for screening applications in zebrafish embryos and larvae.

by Jan Maes, Lien Verlooy, Olivia E Buenafe, Peter A M de Witte, Camila V Esguerra, Alexander D Crawford
Published 2012-01-01

Pharmacological characterization of an antisense knockdown zebrafish model of Dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramine.

by Yifan Zhang, Angéla Kecskés, Daniëlle Copmans, Mélanie Langlois, Alexander D Crawford, Berten Ceulemans, Lieven Lagae, Peter A M de Witte, Camila V Esguerra
Published 2015-01-01

Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants.

by Alexander D Crawford, Sandra Liekens, Appolinary R Kamuhabwa, Jan Maes, Sebastian Munck, Roger Busson, Jef Rozenski, Camila V Esguerra, Peter A M de Witte
Published 2011-02-01

Optimization and pharmacological validation of a leukocyte migration assay in zebrafish larvae for the rapid in vivo bioactivity analysis of anti-inflammatory secondary metabolites...

by María Lorena Cordero-Maldonado, Dany Siverio-Mota, Liliana Vicet-Muro, Isabel María Wilches-Arizábala, Camila V Esguerra, Peter A M de Witte, Alexander D Crawford
Published 2013-01-01

Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs.

by Tatiana Afrikanova, Ann-Sophie K Serruys, Olivia E M Buenafe, Ralph Clinckers, Ilse Smolders, Peter A M de Witte, Alexander D Crawford, Camila V Esguerra
Published 2013-01-01

Zebrafish-based identification of the antiseizure nucleoside inosine from the marine diatom Skeletonema marinoi.

by Théo Brillatz, Chiara Lauritano, Maxime Jacmin, Supitcha Khamma, Laurence Marcourt, Davide Righi, Giovanna Romano, Francesco Esposito, Adrianna Ianora, Emerson F Queiroz, Jean-Luc Wolfender, Alexander D Crawford
Published 2018-01-01

Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B

by Daniëlle Copmans, Sara Kildgaard, Silas A. Rasmussen, Monika Ślęzak, Nina Dirkx, Michèle Partoens, Camila V. Esguerra, Alexander D. Crawford, Thomas O. Larsen, Peter A. M. de Witte
Published 2019-10-01

Deep learning image recognition enables efficient genome editing in zebrafish by automated injections.

by Maria Lorena Cordero-Maldonado, Simon Perathoner, Kees-Jan van der Kolk, Ralf Boland, Ursula Heins-Marroquin, Herman P Spaink, Annemarie H Meijer, Alexander D Crawford, Jan de Sonneville
Published 2019-01-01

A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling.

by Evelien Gebruers, María Lorena Cordero-Maldonado, Alexander I Gray, Carol Clements, Alan L Harvey, Ruangelie Edrada-Ebel, Peter A M de Witte, Alexander D Crawford, Camila V Esguerra
Published 2013-01-01

Integration of Microfractionation, qNMR and zebrafish screening for the in vivo bioassay-guided isolation and quantitative bioactivity analysis of natural products.

by Nadine Bohni, María Lorena Cordero-Maldonado, Jan Maes, Dany Siverio-Mota, Laurence Marcourt, Sebastian Munck, Appolinary R Kamuhabwa, Mainen J Moshi, Camila V Esguerra, Peter A M de Witte, Alexander D Crawford, Jean-Luc Wolfender
Published 2013-01-01