PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma.

PI-3K Inhibitors Preferentially Target CD15+ Cancer Stem Cell Population in SHH Driven Medulloblastoma.

Sonic hedgehog (SHH) medulloblastoma (MB) subtype is driven by a proliferative CD15+ tumor propagating cell (TPC), also considered in the literature as a putative cancer stem cell (CSC). Despite considerable research, much of the biology of this TPC remains unknown. We report evidence that phosphata...

Full description

Bibliographic Details
Main Authors: Alok R Singh, Shweta Joshi, Muamera Zulcic, Michael Alcaraz, Joseph R Garlich, Guillermo A Morales, Yoon J Cho, Lei Bao, Michael L Levy, Robert Newbury, Denise Malicki, Karen Messer, John Crawford, Donald L Durden
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4777592?pdf=render

Internet

http://europepmc.org/articles/PMC4777592?pdf=render

Similar Items