Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function

Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function

Regulatory T cells (Tregs) are a subpopulation of T cells that maintain immunological tolerance. In inflammatory responses the function of Tregs is tightly controlled by several factors including signaling through innate receptors such as Toll like receptors and anaphylatoxin receptors allowing an e...

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Bibliographic Details
Main Authors: Qi Peng, Kulachelvy Ratnasothy, Dominic A. Boardman, Jacinta Jacob, Sim Lai Tung, Daniel McCluskey, Lesley A. Smyth, Robert I. Lechler, Anthony Dorling, Giovanna Lombardi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
protease activated receptor 4 (PAR4)
regulatory T cells (Tregs)
immunoregulation
PI3K/Akt signaling pathway
phosphatase and tensin homolog on chromosome 10 (PTEN)
forkhead box protein O1 (FoxO1)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01311/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01311/full

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