Mesenchymal stem cells inhibit T-cell function through conserved induction of cellular stress.

by Adam G Laing, Giorgia Fanelli, Andrei Ramirez-Valdez, Robert I Lechler, Giovanna Lombardi, Paul T Sharpe
Published 2019-01-01

The Future of Regulatory T Cell Therapy: Promises and Challenges of Implementing CAR Technology

by Yasmin R. Mohseni, Sim L. Tung, Caroline Dudreuilh, Robert I. Lechler, Gilbert O. Fruhwirth, Giovanna Lombardi
Published 2020-07-01

Cell Therapy in Organ Transplantation: Our Experience on the Clinical Translation of Regulatory T Cells

by Niloufar Safinia, Niloufar Safinia, Nathali Grageda, Cristiano Scottà, Sarah Thirkell, Laura J. Fry, Trishan Vaikunthanathan, Robert I. Lechler, Giovanna Lombardi
Published 2018-02-01

Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function

by Qi Peng, Qi Peng, Kulachelvy Ratnasothy, Kulachelvy Ratnasothy, Dominic A. Boardman, Dominic A. Boardman, Jacinta Jacob, Jacinta Jacob, Sim Lai Tung, Sim Lai Tung, Daniel McCluskey, Lesley A. Smyth, Lesley A. Smyth, Robert I. Lechler, Robert I. Lechler, Anthony Dorling, Anthony Dorling, Giovanna Lombardi, Giovanna Lombardi
Published 2019-06-01

Expanded Regulatory T Cells Induce Alternatively Activated Monocytes With a Reduced Capacity to Expand T Helper-17 Cells

by Marco Romano, Giorgia Fanelli, Nicole Tan, Estefania Nova-Lamperti, Estefania Nova-Lamperti, Reuben McGregor, Robert I. Lechler, Giovanna Lombardi, Cristiano Scottà
Published 2018-07-01

Monitoring of in vivo function of superparamagnetic iron oxide labelled murine dendritic cells during anti-tumour vaccination.

by Richard Tavaré, Pervinder Sagoo, Gopal Varama, Yakup Tanriver, Alice Warely, Sandra S Diebold, Richard Southworth, Tobias Schaeffter, Robert I Lechler, Reza Razavi, Giovanna Lombardi, Gregory E D Mullen
Published 2011-01-01

In vivo SPECT reporter gene imaging of regulatory T cells.

by Ehsan Sharif-Paghaleh, Kavitha Sunassee, Richard Tavaré, Kulachelvy Ratnasothy, Alexander Koers, Niwa Ali, Rowa Alhabbab, Philip J Blower, Robert I Lechler, Lesley A Smyth, Gregory E Mullen, Giovanna Lombardi
Published 2011-01-01

A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials

by Henrieta Fraser, Niloufar Safinia, Nathali Grageda, Sarah Thirkell, Katie Lowe, Laura J. Fry, Cristiano Scottá, Andrew Hope, Christopher Fisher, Rachel Hilton, David Game, Paul Harden, Andrew Bushell, Kathryn Wood, Robert I. Lechler, Giovanna Lombardi
Published 2018-03-01

Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment

by Jacinta Jacob, Suchita Nadkarni, Alessia Volpe, Qi Peng, Sim L. Tung, Rosalind F. Hannen, Yasmin R. Mohseni, Cristiano Scotta, Federica M. Marelli-Berg, Robert I. Lechler, Lesley A. Smyth, Gilbert O. Fruhwirth, Giovanna Lombardi
Published 2021-03-01

PD-L1 signaling on human memory CD4+ T cells induces a regulatory phenotype.

by Giorgia Fanelli, Marco Romano, Estefania Nova-Lamperti, Mariana Werner Sunderland, Alessandra Nerviani, Cristiano Scottà, Michele Bombardieri, Sergio A Quezada, Steven H Sacks, Randolph J Noelle, Costantino Pitzalis, Robert I Lechler, Giovanna Lombardi, Pablo D Becker
Published 2021-04-01

An Atlas of Human Regulatory T Helper-like Cells Reveals Features of Th2-like Tregs that Support a Tumorigenic Environment

by Leena Halim, Marco Romano, Reuben McGregor, Isabel Correa, Polychronis Pavlidis, Nathali Grageda, Sec-Julie Hoong, Muhammed Yuksel, Wayel Jassem, Rosalind F. Hannen, Mark Ong, Olivia Mckinney, Bu’Hussain Hayee, Sophia N. Karagiannis, Nicholas Powell, Robert I. Lechler, Estefania Nova-Lamperti, Giovanna Lombardi
Published 2017-07-01

Translational Research in the Time of COVID-19-Dissolving Boundaries.

by Jonathan D Edgeworth, Rahul Batra, Gaia Nebbia, Karen Bisnauthsing, Eithne MacMahon, Malur Sudhanva, Sam Douthwaite, Simon Goldenberg, Geraldine O'Hara, Manu Shankar-Hari, Katie J Doores, Rocio Martinez-Nunez, Carolyn Hemsley, Nicholas M Price, Jill Lockett, Robert I Lechler, Stuart J D Neil, Michael H Malim
Published 2020-09-01

Translational Research in the Time of COVID-19—Dissolving Boundaries

by Jonathan D. Edgeworth, Rahul Batra, Gaia Nebbia, Karen Bisnauthsing, Eithne MacMahon, Malur Sudhanva, Sam Douthwaite, Simon Goldenberg, Geraldine O’Hara, Manu Shankar-Hari, Katie J. Doores, Rocio Martinez-Nunez, Carolyn Hemsley, Nicholas M. Price, Jill Lockett, Robert I. Lechler, Stuart J. D. Neil, Michael H. Malim, Carolyn B. Coyne
Published 2020-09-01

Development and validation of the first consensus gene-expression signature of operational tolerance in kidney transplantation, incorporating adjustment for immunosuppressive drug...

by Sofia Christakoudi, Manohursingh Runglall, Paula Mobillo, Irene Rebollo-Mesa, Tjir-Li Tsui, Estefania Nova-Lamperti, Catharine Taube, Sonia Norris, Yogesh Kamra, Rachel Hilton, Titus Augustine, Sunil Bhandari, Richard Baker, David Berglund, Sue Carr, David Game, Sian Griffin, Philip A. Kalra, Robert Lewis, Patrick B. Mark, Stephen D. Marks, Iain MacPhee, William McKane, Markus G. Mohaupt, Estela Paz-Artal, Sui Phin Kon, Daniel Serón, Manish D. Sinha, Beatriz Tucker, Ondrej Viklický, Daniel Stahl, Robert I. Lechler, Graham M. Lord, Maria P. Hernandez-Fuentes
Published 2020-08-01