Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation

Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation

Tau is a major component of the neurofibrillary tangles (NFT) that represent a pathological hallmark of Alzheimer's disease (AD). Although generally considered an axonal protein, Tau is found in the somato-dendritic compartment of degenerating neurons and this redistribution is thought to be a...

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Bibliographic Details
Main Authors: Shunsuke Kobayashi, Toru Tanaka, Yoshiyuki Soeda, Osborne F.X. Almeida, Akihiko Takashima
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:EBioMedicine
Subjects:
Somatodendritic localization of tau
Tau mRNA
RNP particle
Local translation
AMPA and NMDA receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417302098

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http://www.sciencedirect.com/science/article/pii/S2352396417302098

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