Drug Development Targeting the Glycogen Synthase Kinase-3β (GSK-3β)-Mediated Signal Transduction Pathway: Role of GSK-3β in Adult Brain

by Akihiko Takashima
Published 2009-01-01

New Insights Into Drug Discovery Targeting Tau Protein

by Yoshiyuki Soeda, Akihiko Takashima
Published 2020-12-01

Iso-α-Acids, Bitter Components in Beer, Suppress Inflammatory Responses and Attenuate Neural Hyperactivation in the Hippocampus

by Yasuhisa Ano, Yasuhisa Ano, Misato Yoshikawa, Yuta Takaichi, Makoto Michikawa, Kazuyuki Uchida, Hiroyuki Nakayama, Akihiko Takashima, Akihiko Takashima
Published 2019-02-01

Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory

by Misato Yoshikawa, Misato Yoshikawa, Yoshiyuki Soeda, Yoshiyuki Soeda, Makoto Michikawa, Osborne F. X. Almeida, Akihiko Takashima, Akihiko Takashima
Published 2018-03-01

Enhanced Tau Protein Translation by Hyper-Excitation

by Shunsuke Kobayashi, Toru Tanaka, Yoshiyuki Soeda, Akihiko Takashima
Published 2019-11-01

An Improved Path-Generating Regulator for Two-Wheeled Robots to Track the Circle/Arc Passage

by Jun Dai, Naohiko Hanajima, Toshiharu Kazama, Akihiko Takashima
Published 2014-01-01

Iso-α-Acids, the Bitter Components of Beer, Suppress Microglial Inflammation in rTg4510 Tauopathy

by Yasuhisa Ano, Yuta Takaichi, Kazuyuki Uchida, Keiji Kondo, Hiroyuki Nakayama, Akihiko Takashima
Published 2018-11-01

Local Somatodendritic Translation and Hyperphosphorylation of Tau Protein Triggered by AMPA and NMDA Receptor Stimulation

by Shunsuke Kobayashi, Toru Tanaka, Yoshiyuki Soeda, Osborne F.X. Almeida, Akihiko Takashima
Published 2017-06-01

Amyloid oligomer conformation in a group of natively folded proteins.

by Yuji Yoshiike, Ryoichi Minai, Yo Matsuo, Yun-Ru Chen, Tetsuya Kimura, Akihiko Takashima
Published 2008-01-01

GABA(A) receptor-mediated acceleration of aging-associated memory decline in APP/PS1 mice and its pharmacological treatment by picrotoxin.

by Yuji Yoshiike, Tetsuya Kimura, Shunji Yamashita, Hiroyuki Furudate, Tatsuya Mizoroki, Miyuki Murayama, Akihiko Takashima
Published 2008-01-01

β-Lactolin Reduces Age-Related Inflammation and Cognitive Decline

by Yasuhisa Ano, Yasuhisa Ano, Rena Ohya, Rena Ohya, Akihiko Takashima, Kazuyuki Uchida, Hiroyuki Nakayama
Published 2021-08-01

Phosphorylation and oligomerization of α-synuclein associated with GSK-3β activation in the rTg4510 mouse model of tauopathy

by Yuta Takaichi, James K. Chambers, Hiroyuki Inoue, Yasuhisa Ano, Akihiko Takashima, Hiroyuki Nakayama, Kazuyuki Uchida
Published 2020-06-01

GSK-3beta is required for memory reconsolidation in adult brain.

by Tetsuya Kimura, Shunji Yamashita, Shinobu Nakao, Jung-Mi Park, Miyuki Murayama, Tatsuya Mizoroki, Yuji Yoshiike, Naruhiko Sahara, Akihiko Takashima
Published 2008-01-01

Amyloid β and tau pathology in brains of aged pinniped species (sea lion, seal, and walrus)

by Yuta Takaichi, James K. Chambers, Kei Takahashi, Yoshiyuki Soeda, Riki Koike, Etsuko Katsumata, Chiaki Kita, Fuko Matsuda, Makoto Haritani, Akihiko Takashima, Hiroyuki Nakayama, Kazuyuki Uchida
Published 2021-01-01

Beneficial effects of estrogen in a mouse model of cerebrovascular insufficiency.

by Naohito Kitamura, Runa Araya, Moeko Kudoh, Haruo Kishida, Tetsuya Kimura, Miyuki Murayama, Akihiko Takashima, Yuriko Sakamaki, Tsutomu Hashikawa, Shingo Ito, Sumio Ohtsuki, Tetsuya Terasaki, Jürgen Wess, Masahisa Yamada
Published 2009-01-01

Formation of Filamentous Tau Aggregations in Transgenic Mice Expressing V337M Human Tau

by Kentaro Tanemura, Takumi Akagi, Miyuki Murayama, Naomi Kikuchi, Ohoshi Murayama, Tsutomu Hashikawa, Yuji Yoshiike, Jung-Mi Park, Keiko Matsuda, Shinobu Nakao, Xiaoyan Sun, Shinji Sato, Haruyasu Yamaguchi, Akihiko Takashima
Published 2001-12-01

Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice

by Taiki Kambe, Yumiko Motoi, Ran Inoue, Nobuhiko Kojima, Norihiro Tada, Tetsuya Kimura, Naruhiko Sahara, Shunji Yamashita, Tatsuya Mizoroki, Akihiko Takashima, Kohei Shimada, Koichi Ishiguro, Hiroshi Mizuma, Hirotaka Onoe, Yoshikuni Mizuno, Nobutaka Hattori
Published 2011-06-01

Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice

by Runa Araya, Takanori Noguchi, Munehiro Yuhki, Naohito Kitamura, Makoto Higuchi, Takaomi C. Saido, Kenjiro Seki, Shigeyoshi Itohara, Masako Kawano, Kentaro Tanemura, Akihiko Takashima, Kazuyuki Yamada, Yasushi Kondoh, Iwao Kanno, Jürgen Wess, Masahisa Yamada
Published 2006-11-01

Essential roles of plexin-B3+ oligodendrocyte precursor cells in the pathogenesis of Alzheimer’s disease

by Naomi Nihonmatsu-Kikuchi, Xiu-Jun Yu, Yoshiki Matsuda, Nobuyuki Ozawa, Taeko Ito, Kazuhito Satou, Tadashi Kaname, Yasushi Iwasaki, Akio Akagi, Mari Yoshida, Shuta Toru, Katsuiku Hirokawa, Akihiko Takashima, Masato Hasegawa, Toshiki Uchihara, Yoshitaka Tatebayashi
Published 2021-07-01

Mutation-induced loss of APP function causes GABAergic depletion in recessive familial Alzheimer’s disease: analysis of Osaka mutation-knockin mice

by Tomohiro Umeda, Tetsuya Kimura, Kayo Yoshida, Keizo Takao, Yuki Fujita, Shogo Matsuyama, Ayumi Sakai, Minato Yamashita, Yuki Yamashita, Kiyouhisa Ohnishi, Mamiko Suzuki, Hiroshi Takuma, Tsuyoshi Miyakawa, Akihiko Takashima, Takashi Morita, Hiroshi Mori, Takami Tomiyama
Published 2017-07-01