Pluripotent stem cell‐based screening identifies CUDC‐907 as an effective compound for restoring the in vitro phenotype of Nakajo‐Nishimura syndrome

Pluripotent stem cell‐based screening identifies CUDC‐907 as an effective compound for restoring the in vitro phenotype of Nakajo‐Nishimura syndrome

Abstract Nakajo‐Nishimura syndrome (NNS) is an autoinflammatory disorder caused by a homozygous mutations in the PSMB8 gene. The administration of systemic corticosteroids is partially effective, but continuous treatment causes severe side effects. We previously established a pluripotent stem cell (...

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Bibliographic Details
Main Authors: Naoya Kase, Madoka Terashima, Akira Ohta, Akira Niwa, Fumiko Honda‐Ozaki, Yuri Kawasaki, Tatsutoshi Nakahata, Nobuo Kanazawa, Megumu K. Saito
Format: Article
Language:English
Published: Wiley 2021-03-01
Series:Stem Cells Translational Medicine
Subjects:
chemokines
hereditary autoinflammatory diseases
high‐throughput screening assays
histone deacetylase inhibitors
LMP7 protein
pluripotent stem cells
Online Access:https://doi.org/10.1002/sctm.20-0198

Internet

https://doi.org/10.1002/sctm.20-0198

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