Changing Prevalence and Severity of Childhood Allergic Diseases in Kyoto, Japan, from 1996 to 2006

by Takashi Kusunoki, Takeshi Morimoto, Ryuta Nishikomori, Takahiro Yasumi, Toshio Heike, Tatsuya Fujii, Tatsutoshi Nakahata
Published 2009-01-01

Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity.

by Ryosuke Seki, Akira Ohta, Akira Niwa, Yoshinori Sugimine, Haruna Naito, Tatsutoshi Nakahata, Megumu K Saito
Published 2020-01-01

Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification.

by Shiori Matsuo, Yoko Nishinaka-Arai, Yasuhiro Kazuki, Mitsuo Oshimura, Tatsutoshi Nakahata, Akira Niwa, Megumu K Saito
Published 2021-01-01

Selective development of myogenic mesenchymal cells from human embryonic and induced pluripotent stem cells.

by Tomonari Awaya, Takeo Kato, Yuta Mizuno, Hsi Chang, Akira Niwa, Katsutsugu Umeda, Tatsutoshi Nakahata, Toshio Heike
Published 2012-01-01

The Effect of Past Food Avoidance Due to Allergic Symptoms on the Growth of Children at School Age

by Kumiko Mukaida, Takashi Kusunoki, Takeshi Morimoto, Takahiro Yasumi, Ryuta Nishikomori, Toshio Heike, Tatsuya Fujii, Tatsutoshi Nakahata
Published 2010-01-01

Efficacy of a combination therapy targeting CDK4/6 and autophagy in a mouse xenograft model of t(8;21) acute myeloid leukemia

by Hidemasa Matsuo, Kana Nakatani, Yutarou Harata, Moe Higashitani, Yuri Ito, Aina Inagami, Mina Noura, Tatsutoshi Nakahata, Souichi Adachi
Published 2021-09-01

A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors.

by Akira Niwa, Toshio Heike, Katsutsugu Umeda, Koichi Oshima, Itaru Kato, Hiromi Sakai, Hirofumi Suemori, Tatsutoshi Nakahata, Megumu K Saito
Published 2011-01-01

Pluripotent stem cell‐based screening identifies CUDC‐907 as an effective compound for restoring the in vitro phenotype of Nakajo‐Nishimura syndrome

by Naoya Kase, Madoka Terashima, Akira Ohta, Akira Niwa, Fumiko Honda‐Ozaki, Yuri Kawasaki, Tatsutoshi Nakahata, Nobuo Kanazawa, Megumu K. Saito
Published 2021-03-01

Direct Delivery of piggyBac CD19 CAR T Cells Has Potent Anti-tumor Activity against ALL Cells in CNS in a Xenograft Mouse Model

by Kuniaki Tanaka, Itaru Kato, Miyuki Tanaka, Daisuke Morita, Kazuyuki Matsuda, Yoshiyuki Takahashi, Tatsutoshi Nakahata, Katsutsugu Umeda, Hidefumi Hiramatsu, Souichi Adachi, Junko Takita, Yozo Nakazawa
Published 2020-09-01

N-Acetylcysteine prevents amyloid-β secretion in neurons derived from human pluripotent stem cells with trisomy 21

by Hiromitsu Toshikawa, Akihiro Ikenaka, Li Li, Yoko Nishinaka-Arai, Akira Niwa, Akira Ashida, Yasuhiro Kazuki, Tatsutoshi Nakahata, Hiroshi Tamai, David W. Russell, Megumu K. Saito
Published 2021-08-01

Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres.

by Takehiro Iki, Michihiro Tanaka, Shin-Ichiro Kitajiri, Tomoko Kita, Yuri Kawasaki, Akifumi Mizukoshi, Wataru Fujibuchi, Takayuki Nakagawa, Tatsutoshi Nakahata, Juichi Ito, Koichi Omori, Megumu K Saito
Published 2017-01-01

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1

by Hongtao Wang, Cuicui Liu, Xin Liu, Mengge Wang, Dan Wu, Jie Gao, Pei Su, Tatsutoshi Nakahata, Wen Zhou, Yuanfu Xu, Lihong Shi, Feng Ma, Jiaxi Zhou
Published 2018-02-01

Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis.

by Itaru Kato, Akira Niwa, Toshio Heike, Hisanori Fujino, Megumu K Saito, Katsutsugu Umeda, Hidefumi Hiramatsu, Mamoru Ito, Makiko Morita, Yoko Nishinaka, Souichi Adachi, Fumihiko Ishikawa, Tatsutoshi Nakahata
Published 2011-01-01

Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease.

by Naoki Yahata, Masashi Asai, Shiho Kitaoka, Kazutoshi Takahashi, Isao Asaka, Hiroyuki Hioki, Takeshi Kaneko, Kei Maruyama, Takaomi C Saido, Tatsutoshi Nakahata, Takashi Asada, Shinya Yamanaka, Nobuhisa Iwata, Haruhisa Inoue
Published 2011-01-01

Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-Derived iPSCs

by Michiko Yoshida, Shiho Kitaoka, Naohiro Egawa, Mayu Yamane, Ryunosuke Ikeda, Kayoko Tsukita, Naoki Amano, Akira Watanabe, Masafumi Morimoto, Jun Takahashi, Hajime Hosoi, Tatsutoshi Nakahata, Haruhisa Inoue, Megumu K. Saito
Published 2015-04-01

Overexpression of GATA2 Enhances Development and Maintenance of Human Embryonic Stem Cell-Derived Hematopoietic Stem Cell-like Progenitors

by Ya Zhou, Yonggang Zhang, Bo Chen, Yong Dong, Yimeng Zhang, Bin Mao, Xu Pan, Mowen Lai, Yijin Chen, Guohui Bian, Qiongxiu Zhou, Tatsutoshi Nakahata, Jiaxi Zhou, Min Wu, Feng Ma
Published 2019-07-01

Early Development of Definitive Erythroblasts from Human Pluripotent Stem Cells Defined by Expression of Glycophorin A/CD235a, CD34, and CD36

by Bin Mao, Shu Huang, Xulin Lu, Wencui Sun, Ya Zhou, Xu Pan, Jinfeng Yu, Mowen Lai, Bo Chen, Qiongxiu Zhou, Song Mao, Guohui Bian, Jiaxi Zhou, Tatsutoshi Nakahata, Feng Ma
Published 2016-11-01

Using patient-derived iPSCs to develop humanized mouse models for chronic myelomonocytic leukemia and therapeutic drug identification, including liposomal clodronate

by Kazuki Taoka, Shunya Arai, Keisuke Kataoka, Masataka Hosoi, Masashi Miyauchi, Sho Yamazaki, Akira Honda, Wei Aixinjueluo, Takashi Kobayashi, Keiki Kumano, Akihide Yoshimi, Makoto Otsu, Akira Niwa, Tatsutoshi Nakahata, Hiromitsu Nakauchi, Mineo Kurokawa
Published 2018-10-01

Robust and highly-efficient differentiation of functional monocytic cells from human pluripotent stem cells under serum- and feeder cell-free conditions.

by Masakatsu D Yanagimachi, Akira Niwa, Takayuki Tanaka, Fumiko Honda-Ozaki, Seiko Nishimoto, Yuuki Murata, Takahiro Yasumi, Jun Ito, Shota Tomida, Koichi Oshima, Isao Asaka, Hiroaki Goto, Toshio Heike, Tatsutoshi Nakahata, Megumu K Saito
Published 2013-01-01

Derivation of mesenchymal stromal cells from pluripotent stem cells through a neural crest lineage using small molecule compounds with defined media.

by Makoto Fukuta, Yoshinori Nakai, Kosuke Kirino, Masato Nakagawa, Kazuya Sekiguchi, Sanae Nagata, Yoshihisa Matsumoto, Takuya Yamamoto, Katsutsugu Umeda, Toshio Heike, Naoki Okumura, Noriko Koizumi, Takahiko Sato, Tatsutoshi Nakahata, Megumu Saito, Takanobu Otsuka, Shigeru Kinoshita, Morio Ueno, Makoto Ikeya, Junya Toguchida
Published 2014-01-01