Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage

Miswired Enhancer Logic Drives a Cancer of the Muscle Lineage

Summary: Core regulatory transcription factors (CR TFs) establish enhancers with logical ordering during embryogenesis and development. Here we report that in fusion-positive rhabdomyosarcoma, a cancer of the muscle lineage, the chief oncogene PAX3-FOXO1 is driven by a translocated FOXO1 super enhan...

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Bibliographic Details
Main Authors: Berkley E. Gryder, Marco Wachtel, Kenneth Chang, Osama El Demerdash, Nicholas G. Aboreden, Wardah Mohammed, Winston Ewert, Silvia Pomella, Rossella Rota, Jun S. Wei, Young Song, Benjamin Z. Stanton, Beat Schäfer, Christopher R. Vakoc, Javed Khan
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:iScience
Subjects:
Biological Sciences
Chromosome Organization
Molecular Mechanism of Gene Regulation
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220302881

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http://www.sciencedirect.com/science/article/pii/S2589004220302881

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