Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2

Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2

Matriptase is ectopically expressed in neoplastic B-cells, in which matriptase activity is enhanced by negligible expression of its endogenous inhibitor, hepatocyte growth factor activator inhibitor (HAI)-1. HAI-1, however, is also involved in matriptase synthesis and intracellular trafficking. The...

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Bibliographic Details
Main Authors: Yi-Lin Chiu, Yi-Ying Wu, Robert B. Barndt, Yee Hui Yeo, Yu-Wen Lin, Hou-Ping Sytwo, Huan-Cheng Liu, Yuan Xu, Bailing Jia, Jehng-Kang Wang, Michael D. Johnson, Chen-Yong Lin
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
matriptase
protease inhibition
hai-1
hai-2
b-cell lymphoma
pericellular proteolytic activity
Online Access:http://dx.doi.org/10.1080/14756366.2019.1577831

Internet

http://dx.doi.org/10.1080/14756366.2019.1577831

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