Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity.

by Chun-Che Tseng, Bailing Jia, Robert Barndt, Yayun Gu, Chien-Yu Chen, I-Chu Tseng, Sheng-Fang Su, Jehng-Kang Wang, Michael D Johnson, Chen-Yong Lin
Published 2017-01-01

Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2.

by Frank Shiao, Li-Ching O Liu, Nanxi Huang, Ying-Jung J Lai, Robert J Barndt, Chun-Che Tseng, Jehng-Kang Wang, Bailing Jia, Michael D Johnson, Chen-Yong Lin
Published 2017-01-01

The intracellular seven amino acid motif EEGEVFL is required for matriptase vesicle sorting and translocation to the basolateral plasma membrane.

by Chun-Che Tseng, Bailing Jia, Robert B Barndt, Yang-Hong Dai, Yu Hsin Chen, Po-Wen A Du, Jehng-Kang Wang, Hung-Jen Tang, Chen-Yong Lin, Michael D Johnson
Published 2020-01-01

Aberrant regulation favours matriptase proteolysis in neoplastic B-cells that co-express HAI-2

by Yi-Lin Chiu, Yi-Ying Wu, Robert B. Barndt, Yee Hui Yeo, Yu-Wen Lin, Hou-Ping Sytwo, Huan-Cheng Liu, Yuan Xu, Bailing Jia, Jehng-Kang Wang, Michael D. Johnson, Chen-Yong Lin
Published 2019-01-01