HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages

HDAC3 Mediates the Inflammatory Response and LPS Tolerance in Human Monocytes and Macrophages

Histone deacetylases (HDACs) are a group of enzymes that control histone deacetylation and bear potential to direct expression of large gene sets. We determined the effect of HDAC inhibitors (HDACi) on human monocytes and macrophages, with respect to their polarization, activation, and their capabil...

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Bibliographic Details
Main Authors: Mohammed Ghiboub, Jing Zhao, Andrew Y. F. Li Yim, Ronald Schilderink, Caroline Verseijden, Patricia H. P. van Hamersveld, Jose M. Duarte, Theodorus B. M. Hakvoort, Iris Admiraal, Nicola R. Harker, David F. Tough, Peter Henneman, Menno P. J. de Winther, Wouter J. de Jonge
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
IFNγ
macrophages
HDAC3 inhibition
LPS tolerance
inflammatory response
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.550769/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.550769/full

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