IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells.

IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells.

Activation of the IKK-NFκB pathway increases the resistance of cancer cells to ionizing radiation (IR). This effect has been largely attributed to the induction of anti-apoptotic proteins by NFκB. Since efficient repair of DNA double strand breaks (DSBs) is required for the clonogenic survival of ir...

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Bibliographic Details
Main Authors: Lixian Wu, Lijian Shao, Ningfei An, Junru Wang, Senthil Pazhanisamy, Wei Feng, Martin Hauer-Jensen, Shigeki Miyamoto, Daohong Zhou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3072401?pdf=render

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http://europepmc.org/articles/PMC3072401?pdf=render

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