Recombinant Protein-Based Nanoparticles: Elucidating their Inflammatory Effects In Vivo and their Potential as a New Therapeutic Format

Recombinant Protein-Based Nanoparticles: Elucidating their Inflammatory Effects In Vivo and their Potential as a New Therapeutic Format

Bacterial inclusion bodies (IBs) are protein-based nanoparticles of a few hundred nanometers formed during recombinant protein production processes in different bacterial hosts. IBs contain active protein in a mechanically stable nanostructured format that has been broadly characterized, showing pro...

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Bibliographic Details
Main Authors: Laia Gifre-Renom, Estefania Ugarte-Berzal, Erik Martens, Lise Boon, Olivia Cano-Garrido, Esther Martínez-Núñez, Teresa Luque, Ramon Roca-Pinilla, Òscar Conchillo-Solé, Neus Ferrer-Miralles, Antonio Villaverde, Ghislain Opdenakker, Elena Garcia-Fruitós, Anna Arís
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Pharmaceutics
Subjects:
inclusion body
matrix metalloproteinase-9
mmp9 knock-out mice
functional nanoparticle
immunogenicity
Online Access:https://www.mdpi.com/1999-4923/12/5/450

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https://www.mdpi.com/1999-4923/12/5/450

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