Neutrophils: Underestimated Players in the Pathogenesis of Multiple Sclerosis (MS)

by Mirre De Bondt, Niels Hellings, Ghislain Opdenakker, Sofie Struyf
Published 2020-06-01

Endothelial response to glucocorticoids in inflammatory diseases

by Karolina A Zielinska, Laura Van Moortel, Ghislain Opdenakker, Karolien De Bosscher, Philippe E Van Den Steen
Published 2016-12-01

Differential inhibition of activity, activation and gene expression of MMP-9 in THP-1 cells by azithromycin and minocycline versus bortezomib: A comparative study.

by Jennifer Vandooren, Sofie Knoops, João L Aldinucci Buzzo, Lise Boon, Erik Martens, Ghislain Opdenakker, Elzbieta Kolaczkowska
Published 2017-01-01

Inhibition of Neutrophil Collagenase/MMP-8 and Gelatinase B/MMP-9 and Protection against Endotoxin Shock

by Zheng Qiu, Jianghai Chen, Hanmei Xu, Philippe E. Van den Steen, Ghislain Opdenakker, Min Wang, Jialiang Hu
Published 2014-01-01

MMP-9/Gelatinase B Degrades Immune Complexes in Systemic Lupus Erythematosus

by Estefania Ugarte-Berzal, Lise Boon, Erik Martens, Vasily Rybakin, Daniel Blockmans, Jennifer Vandooren, Paul Proost, Ghislain Opdenakker
Published 2019-03-01

Natural haemozoin induces expression and release of human monocyte tissue inhibitor of metalloproteinase-1.

by Manuela Polimeni, Elena Valente, Daniela Ulliers, Ghislain Opdenakker, Philippe E Van den Steen, Giuliana Giribaldi, Mauro Prato
Published 2013-01-01

CCR2 Is Dispensable for Disease Resolution but Required for the Restoration of Leukocyte Homeostasis Upon Experimental Malaria-Associated Acute Respiratory Distress Syndrome

by Emilie Pollenus, Thao-Thy Pham, Leen Vandermosten, Hendrik Possemiers, Sofie Knoops, Ghislain Opdenakker, Philippe E. Van den Steen
Published 2021-02-01

Direct visualization of protease action on collagen triple helical structure.

by Gabriel Rosenblum, Philippe E Van den Steen, Sidney R Cohen, Arkady Bitler, David D Brand, Ghislain Opdenakker, Irit Sagi
Published 2010-06-01

Interference with glycosaminoglycan-chemokine interactions with a probe to alter leukocyte recruitment and inflammation in vivo.

by Sandra Li, Ulrika S Pettersson, Bart Hoorelbeke, Elzbieta Kolaczkowska, Katrien Schelfhout, Erik Martens, Paul Kubes, Jo Van Damme, Mia Phillipson, Ghislain Opdenakker
Published 2014-01-01

Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis.

by Estefania Ugarte-Berzal, Nele Berghmans, Lise Boon, Erik Martens, Jennifer Vandooren, Bénédicte Cauwe, Greet Thijs, Paul Proost, Jo Van Damme, Ghislain Opdenakker
Published 2018-01-01

Neutrophils and Activated Macrophages Control Mucosal Immunity by Proteolytic Cleavage of Antileukoproteinase

by Jennifer Vandooren, Pieter Goeminne, Pieter Goeminne, Lise Boon, Estefania Ugarte-Berzal, Vasily Rybakin, Paul Proost, Ahmed M. Abu El-Asrar, Ghislain Opdenakker
Published 2018-05-01

Relationship between vitreous levels of matrix metalloproteinases and vascular endothelial growth factor in proliferative diabetic retinopathy.

by Ahmed M Abu El-Asrar, Ghulam Mohammad, Mohd Imtiaz Nawaz, Mohammad Mairaj Siddiquei, Kathleen Van den Eynde, Ahmed Mousa, Gert De Hertogh, Ghislain Opdenakker
Published 2013-01-01

Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice.

by Nathalie Geurts, Erik Martens, Sebastien Verhenne, Natacha Lays, Greet Thijs, Stefan Magez, Bénédicte Cauwe, Sandra Li, Hubertine Heremans, Ghislain Opdenakker, Philippe E Van den Steen
Published 2011-01-01

Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration

by Jian Song, Chuan Wu, Eva Korpos, Xueli Zhang, Smriti M. Agrawal, Ying Wang, Cornelius Faber, Michael Schäfers, Heinrich Körner, Ghislain Opdenakker, Rupert Hallmann, Lydia Sorokin
Published 2015-02-01

Neurotrophins and neurotrophin receptors in proliferative diabetic retinopathy.

by Ahmed M Abu El-Asrar, Ghulam Mohammad, Gert De Hertogh, Mohd Imtiaz Nawaz, Kathleen Van Den Eynde, Mohammad Mairaj Siddiquei, Sofie Struyf, Ghislain Opdenakker, Karel Geboes
Published 2013-01-01

Matrix Metalloproteinase-9-Generated COOH-, but Not NH2-Terminal Fragments of Serum Amyloid A1 Retain Potentiating Activity in Neutrophil Migration to CXCL8, With Loss of Direct Ch...

by Mieke Gouwy, Mieke De Buck, Sara Abouelasrar Salama, Jennifer Vandooren, Sofie Knoops, Noëmie Pörtner, Lotte Vanbrabant, Nele Berghmans, Ghislain Opdenakker, Paul Proost, Jo Van Damme, Sofie Struyf
Published 2018-06-01

Pathogenic CD8+ T Cells Cause Increased Levels of VEGF-A in Experimental Malaria-Associated Acute Respiratory Distress Syndrome, but Therapeutic VEGFR Inhibition Is Not Effective

by Thao-Thy Pham, Melissa Verheijen, Leen Vandermosten, Katrien Deroost, Sofie Knoops, Kathleen Van den Eynde, Louis Boon, Chris J. Janse, Ghislain Opdenakker, Philippe E. Van den Steen
Published 2017-09-01

Increase in sialylation and branching in the mouse serum N-glycome correlates with inflammation and ovarian tumour progression.

by Radka Saldova, Helene Piccard, Marta Pérez-Garay, David J Harvey, Weston B Struwe, Marie C Galligan, Nele Berghmans, Stephen F Madden, Rosa Peracaula, Ghislain Opdenakker, Pauline M Rudd
Published 2013-01-01

Hemozoin induces hepatic inflammation in mice and is differentially associated with liver pathology depending on the Plasmodium strain.

by Katrien Deroost, Natacha Lays, Thao-Thy Pham, Denisa Baci, Kathleen Van den Eynde, Mina Komuta, Mauro Prato, Tania Roskams, Evelin Schwarzer, Ghislain Opdenakker, Philippe E Van den Steen
Published 2014-01-01

Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases

by Jennifer Vandooren, Rafaela Vaz Sousa Pereira, Estefania Ugarte-Berzal, Vasily Rybakin, Sam Noppen, Melissa R. Stas, Eline Bernaerts, Eva Ganseman, Mieke Metzemaekers, Dominique Schols, Paul Proost, Ghislain Opdenakker
Published 2021-06-01