A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders

A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders

The acetylcholinesterase (AChE) inhibitors are the main drugs for symptomatic treatment of neurodegenerative disorders like Alzheimer’s disease. A recently designed, synthesized and tested hybrid compound between the AChE inhibitor galantamine (GAL) and the antioxidant polyphenol curcumin (CU) showe...

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Bibliographic Details
Main Authors:	Rumyana Simeonova, Dimitrina Zheleva, Iva Valkova, Georgi Stavrakov, Irena Philipova, Mariyana Atanasova, Irini Doytchinova
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	Molecules
Subjects:	galantamine curcumin in vivo AChE inhibition acute toxicity in mice BBB permeability by PAMPA, antioxidant activity malondialdehide levels
Online Access:	https://www.mdpi.com/1420-3049/26/7/1865

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