A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders

A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders

The acetylcholinesterase (AChE) inhibitors are the main drugs for symptomatic treatment of neurodegenerative disorders like Alzheimer’s disease. A recently designed, synthesized and tested hybrid compound between the AChE inhibitor galantamine (GAL) and the antioxidant polyphenol curcumin (CU) showe...

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Bibliographic Details
Main Authors: Rumyana Simeonova, Dimitrina Zheleva, Iva Valkova, Georgi Stavrakov, Irena Philipova, Mariyana Atanasova, Irini Doytchinova
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Molecules
Subjects:
galantamine
curcumin
in vivo AChE inhibition
acute toxicity in mice
BBB permeability by PAMPA, antioxidant activity
malondialdehide levels
Online Access:https://www.mdpi.com/1420-3049/26/7/1865

Internet

https://www.mdpi.com/1420-3049/26/7/1865

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