Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-<i>Plasmodium falciparum</i> Activities

Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-<i>Plasmodium falciparum</i> Activities

7-Benzylidenenaltrexone (BNTX) and most of its derivatives showed in vitro antimalarial activities against chloroquine-resistant and -sensitive <i>Plasmodium falciparum</i> strains (K1 and FCR3, respectively). In addition, the time-dependent changes of the addition reactions of the BNTX...

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Bibliographic Details
Main Authors: Noriki Kutsumura, Yasuaki Koyama, Tsuyoshi Saitoh, Naoshi Yamamoto, Yasuyuki Nagumo, Yoshiyuki Miyata, Rei Hokari, Aki Ishiyama, Masato Iwatsuki, Kazuhiko Otoguro, Satoshi Ōmura, Hiroshi Nagase
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
morphinan
bntx
δ opioid receptor antagonist
<sup>1</sup>h-nmr experiments
mechanism elucidation
Online Access:https://www.mdpi.com/1420-3049/25/5/1112

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https://www.mdpi.com/1420-3049/25/5/1112

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