Opening the OPK Assay Gatekeeper: Harnessing Multi-Modal Protection by Pneumococcal Vaccines

Pneumococcal vaccine development is driven by the achievement of high activity in a single gatekeeper assay: the bacterial opsonophagocytic killing (OPK) assay. New evidence challenges the dogma that anti-capsular antibodies have only a single function that predicts success. The emerging concept of...

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Bibliographic Details
Main Authors: Ashleigh N. Riegler, Beth Mann, Carlos J. Orihuela, Elaine Tuomanen
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Pathogens
Subjects:
Online Access:https://www.mdpi.com/2076-0817/8/4/203