The Emerging Role of the Major Histocompatibility Complex Class I in Amyotrophic Lateral Sclerosis

The Emerging Role of the Major Histocompatibility Complex Class I in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting upper and lower motoneurons (MNs). The etiology of the disease is still unknown for most patients with sporadic ALS, while in 5–10% of the familial cases, several gene mutations have been linked to the disease. Mutati...

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Bibliographic Details
Main Authors: Gabriela Bortolança Chiarotto, Giovanni Nardo, Maria Chiara Trolese, Marcondes Cavalcante França Jr., Caterina Bendotti, Alexandre Leite Rodrigues de Oliveira
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:International Journal of Molecular Sciences
Subjects:
major histocompatibility complex I
amyotrophic lateral sclerosis
glial cells
microglia
neuroprotection
Online Access:https://www.mdpi.com/1422-0067/18/11/2298

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https://www.mdpi.com/1422-0067/18/11/2298

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